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. 2018 Jan 10;38(1):BSR20171148. doi: 10.1042/BSR20171148

Figure 8. Reagents and reaction conditions of 3-deazathiamine synthesis.

Figure 8

(a) (1) Br2, CHCl3; (2) KOH/EtOH, (b) Zn, AcOH [88] or s-BuLi [89], (c) n-BuLi, ethylene oxide, BF3.Et2O, (d) n-BuLi (2 eq), DMF, (e) 3-anilinopropionitrile, NaOMe/MeOH, DMSO, (f) acetamidine hydrochloride, NaOEt/EtOH, (g) SO2Cl2, (h) AcOH, HCl, Ac2O, (i) (1) NaHS; (2) ethyl 3-ethoxyacrylate, LiHMDS; (3) HCl, (j) NCCH2COOEt, AcONH4, C6H5CH3, (k) NaSH, EtOH, (l) CuBr2, t-BuONO, CH3CN, (m) Zn, AcOH, (n) LiAlH4, Et2O, (o) MnO2, CHCl3.