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. 2018 Jan 10;38(1):BSR20171302. doi: 10.1042/BSR20171302

Figure 1. Myocardial iron overload in an aged murine model of iron-overload cardiomyopathy.

Figure 1

(A) Schematic representation of the study design. (B) Representative images for Prussian Blue staining with quantitation (n=8: four hearts; two sections per heart). (C) Total myocardial tissue iron levels (n=8 hearts). (D) Expression of iron metabolic genes: HJV and hepcidin (Hamp). (E) Expression of iron transporting genes: ferroportin (FPN1) and transferrin receptor 1 (Trfc). (F) Expression of iron storage genes: ferritin light (L) chain and ferritin heavy (H) chain. n=8 (hearts) for gene expression analysis (D–F); *P<0.05 compared with the Ctl group. ‡P<0.05 compared with the WT standard group. Abbreviations: Ctl, HJV control; Fe, iron diet; Fe + R, iron diet + resveratrol; ND, not detected.