Table 1. Echocardiographic assessment of cardiac function and blood pressure in male HJVKO mice at 1 year of age.
| HJVKO + vehicle | HJVKO + iron + placebo | HJVKO + iron + resveratrol | |
|---|---|---|---|
| n | 8 | 11 | 9 |
| HR (echo) (bpm) | 446 ± 13 (0.082) | 433 ± 14 (0.107) | 410 ± 11 (0.080) |
| E-wave (mm/s) | 670 ± 47 (0.198) | 682 ± 36 (0.175) | 632 ± 18 (0.085) |
| A-wave (mm/s) | 490 ± 45 (0.260) | 437 ± 30 (0.228) | 372 ± 33 (0.266) |
| E/A ratio | 1.57 ± 0.10 (0.180) | 1.49 ± 0.15 (0.334) | 1.80 ± 0.20 (0.333) |
| DT (ms) | 24.9 ± 1.0 (0.114) | 32.8 ± 2.1* (0.216) | 26.7 ± 2.2 (0.247) |
| EWDR (mm/s2) | 27.4 ± 1.8 (0.184) | 21.9 ± 2.2 (0.330) | 24.7 ± 2.0 (0.244) |
| E′ (mm/s) | 24.6 ± 1.3 (0.153) | 20.1 ± 1.6 (0.264) | 24.5 ± 1.6 (0.196) |
| A′ (mm/s) | 20.1 ± 1.5 (0.211) | 26.5 ± 1.5* (0.188) | 20.4 ± 1.4† (0.200) |
| E/E′ ratio | 27.2 ± 2.5 (0.258) | 33.9 ± 2.2 (0.212) | 26.4 ± 1.6† (0.176) |
| LA size (mm) | 1.92 ± 0.08 (0.118) | 2.20 ± 0.06* (0.090) | 1.79 ± 0.09† (0.151) |
| LVEDD (mm) | 3.94 ± 0.12 (0.086) | 4.12 ± 0.08 (0.064) | 3.73 ± 0.09† (0.072) |
| LVESD (mm) | 2.59 ± 0.13 (0.142) | 3.13 ± 0.08* (0.085) | 2.45 ± 0.07† (0.086) |
| VCFc (circ/s) | 7.1 ± 0.4 (0.159) | 5.1 ± 0.2* (0.130) | 7.1 ± 0.2† (0.101) |
| LVPWT (mm) | 0.76 ± 0.03 (0.112) | 0.93 ± 0.05* (0.178) | 0.83 ± 0.04 (0.145) |
| HR (BP) (bmp) | 425 ± 13 (0.084) | 426 ± 16 (0.124) | 407 ± 8 (0.060) |
| SBP (mmHg) | 141 ± 4 (0.080) | 139 ± 6 (0.148) | 141 ± 5 (0.100) |
| DBP (mmHg) | 93.3 ± 2.3 (0.070) | 95.0 ± 3.3 (0.115) | 96.0 ± 3.1 (0.097) |
| MAP (mmHg) | 125 ± 3.3 (0.075) | 125 ± 5.1 (0.136) | 126 ± 4.1 (0.098) |
Data are presented as mean ± S.E.M. (coefficient of variation). *P<0.05 compared with vehicle group, †P<0.05 compared with iron group. Abbreviations: A, atrial transmitral filling wave; A′, tissue Doppler due to atrial contraction; DBP, diastolic blood pressure; DT, deceleration time; E, early transmitral filling wave; E′, early tissue Doppler velocity; EWDR, E-wave deceleration rate; HR, heart rate; LA, left atrium; LVEDD, LV end-diastolic dimension; LVESD, LV end-systolic dimension; LVPWT, LV posterior wall thickness; MAP, mean arterial pressure; SBP, systolic blood pressure; VCFc, velocity of circumferential fiber shortening.