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. 2019 Mar 20;10:268. doi: 10.3389/fphys.2019.00268

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Copyright © 2019 Rocha, Claudio, da Silva, Cordeiro, Domingos, da Cunha, Mauad, Nascimento, Lima-Leopoldo and Leopoldo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Concentration-response curve to leptin in the thoracic aorta from C and Ob groups in the presence or absence of L-NAME (100 μM – A) or Akt inhibitor (5 μM – B). Parentheses indicates the number of rings and rats, respectively. Data are presented as mean ± SEM. Two-way ANOVA was used followed by the Fisher′s post hoc test for multiple comparisons. ^∗p < 0.05 Ob vs. C.