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Rule of thumb for area distribution in a drug substance production building.
| Area | Size distribution |
|---|---|
| Process support (labs, wash/prep, autoclave) | 5 – 10% |
| Building circulation (corridors and airlocks) | 8 – 17% |
| Personnel (lockers, offices, etc.) | 5 – 15% |
| Material handling (storage) | 5 – 15% |
| Mechanical (HVAC, utilities, electrical, chases) | 35 – 50% |
| Process areas (fermentation, purification, buffer/media) | 15 – 20% |
