Table 4.

Frequency of cognitive impairment (CI) in patients with CIS compared with patients with RRMS.

References	CIS n	RR n	% CI* CIS	%CI* RR	Age CIS	Age RRMS	DD CIS (years)	DD RRMS (years)
Potagas et al. (17)	33	75	27.3	40.0	34.7 (8.7)	34.3 (8.9)	1.0 (1.5)	6.2 (4.9)
Khalil et al. (19)	44	80	18.2	21.3	33.9 (10.0)	37.0 (9.6)	0.2 (0.1–0.8)	8.1 (4.2–13.8)
Ruano et al. (10)	167	759	34.5	44.5	33.9 (9.8)	39.9 (10.2)	1.4 (2.2)	11.2 (8.4)

CIS, clinically isolated syndromes; RR, relapsing-remitting; DD, Disease duration; CI, cognitive impairment.

^*Definition of CI in each study (see Table 1).