(A) OD value in response to the treatment of miR-182-5p mimic, miR-182-5p inhibitor, si-ADCY6, miR-182-5p inhibitor + si-ADCY6, U0126 or miR-182-5p inhibitor + U0126 measured by MTT assay; (B) the gray value of PCNA protein band in response to the treatment of miR-182-5p mimic, miR-182-5p inhibitor, si-ADCY6, miR-182-5p inhibitor + si-ADCY6, U0126 or miR-182-5p inhibitor + U0126; (C) PCNA protein level in response to the treatment of miR-182-5p mimic, miR-182-5p inhibitor, si-ADCY6, miR-182-5p inhibitor + si-ADCY6, U0126 or miR-182-5p inhibitor + U0126; *, P < 0.05 vs. the blank group and the NC group; #, P < 0.05 vs. the miR-182-5p inhibitor group. NC, negative control; PCNA, proliferating cell nuclear antigen; miR-182-5p, microRNA-182-5p.