Table 4. Subgroup analysis of preoperative serum albumin and the prognosis of UC patients.
| Variables | Outcome | Studies | Patients | HR (95% CI) | P-value | Model | Heterogeneity | |
|---|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | |||||||
| Tumor type | ||||||||
| UTUC | OS | 4 | 841 | 2.03 (1.34, 3.07) | <0.01 | Random | 78 | <0.01 |
| CSS | 6 | 900 | 1.69 (1.16, 2.46) | <0.01 | Random | 87 | <0.01 | |
| RFS | 3 | 553 | 3.11 (2.17, 4.46) | <0.01 | Fixed | 0 | 0.59 | |
| 30dC | 1 | 5735 | 3.14 (2.86, 3.45) | - | - | - | - | |
| 90dM | 1 | 2669 | 7.66 (5.80, 10.12) | - | - | - | - | |
| BC | OS | 8 | 3288 | 1.80 (1.38, 2.33) | <0.01 | Random | 60 | 0.01 |
| CSS | 6 | 1328 | 1.69 (1.16, 2.46) | <0.01 | Random | 87 | <0.01 | |
| RFS | 3 | 2210 | 1.19 (0.85, 1.68) | 0.32 | Random | 72 | 0.03 | |
| 30dC | 6 | 5568 | 1.55 (1.19, 2.02) | <0.01 | Random | 62 | 0.02 | |
| 90dM | 5 | 5568 | 2.87 (1.89, 4.36) | <0.01 | Fixed | 14 | 0.33 | |
| Ethnicity | ||||||||
| Asian | OS | 6 | 1665 | 1.59 (1.09, 2.32) | 0.02 | Random | 62 | 0.02 |
| CSS | 6 | 1731 | 2.03 (1.17, 3.54) | 0.01 | Random | 82 | <0.01 | |
| RFS | 4 | 1477 | 1.60 (0.90, 2.86) | 0.11 | Random | 87 | <0.01 | |
| Non-Asian | OS | 6 | 2271 | 2.20 (1.50, 3.23) | <0.01 | Random | 67 | 0.01 |
| CSS | 3 | 497 | 2.02 (1.28, 3.19) | <0.01 | Random | 75 | 0.02 | |
| RFS | 2 | 1286 | 2.56 (1.00, 6.52) | 0.05 | Random | 80 | 0.03 | |
| Analysis type | ||||||||
| Univariate | OS | 10 | 3859 | 1.70 (1.31, 2.20) | <0.01 | Random | 62 | <0.01 |
| CSS | 4 | 953 | 2.25 (1.46, 3.47) | <0.01 | Fixed | 43 | 0.15 | |
| RFS | 2 | 247 | 1.64 (0.23, 11.53) | 0.62 | Random | 92 | <0.01 | |
| 30dC | 2 | 6939 | 2.35 (1.43, 3.87) | <0.01 | Random | 82 | <0.01 | |
| 90dM | 5 | 7140 | 4.64 (2.15, 10.03) | <0.01 | Random | 82 | <0.01 | |
| Multivariate | OS | 2 | 270 | 4.21 (2.23, 7.94) | <0.01 | Fixed | 0 | 0.45 |
| CSS | 5 | 1275 | 1.81 (1.14, 2.87) | 0.01 | Random | 88 | <0.01 | |
| RFS | 4 | 2516 | 1.33 (0.91, 1.94) | 0.13 | Random | 75 | <0.01 | |
| 30dC | 5 | 4364 | 1.46 (1.06, 2.00) | 0.02 | Random | 62 | 0.05 | |
| 90dM | 1 | 1097 | 3.03 (1.33, 6.90) | - | - | - | - | |
| Cut-off value | ||||||||
| =3.5 g/dl | OS | 10 | 3859 | 1.70 (1.31, 2.20) | <0.01 | Random | 62 | <0.01 |
| CSS | 5 | 1216 | 2.11 (1.40, 3.17) | <0.01 | Random | 55 | 0.06 | |
| RFS | 3 | 2061 | 1.74 (1.04, 2.91) | 0.03 | Random | 75 | 0.02 | |
| 30dC | 5 | 8726 | 2.09 (1.35, 3.25) | <0.01 | Random | 87 | <0.01 | |
| 90dM | 5 | 8068 | 4.92 (2.35, 10.31) | <0.01 | Random | 74 | <0.01 | |
| Others | OS | 2 | 270 | 4.21 (2.23, 7.94) | <0.01 | Fixed | 0 | 0.45 |
| CSS | 4 | 1012 | 1.92 (1.06, 3.47) | 0.03 | Random | 89 | <0.01 | |
| RFS | 3 | 702 | 2.14 (0.77, 5.97) | 0.15 | Random | 90 | <0.01 | |
| 30dC | 2 | 2577 | 1.40 (0.78, 2.52) | 0.27 | Random | 55 | 0.14 | |
| 90dM | 1 | 169 | 2.50 (1.40, 4.46) | - | - | - | - | |
| Sample size | ||||||||
| n>600 | OS | 2 | 1915 | 1.48 (0.83, 2.65) | 0.18 | Random | 75 | 0.05 |
| RFS | 4 | 1915 | 2.30 (1.02, 5.18) | 0.13 | Random | 49 | 0.16 | |
| 30dC | 5 | 10842 | 1.73 (0.98, 3.08) | 0.06 | Random | 98 | <0.01 | |
| 90dM | 3 | 387 | 4.01 (1.72, 9.32) | <0.01 | Random | 86 | <0.01 | |
| n<600 | OS | 10 | 2214 | 2.02 (1.45, 2.81) | <0.01 | Random | 67 | <0.01 |
| RFS | 2 | 848 | 1.39 (0.90, 2.14) | 0.05 | Random | 92 | <0.01 | |
| 30dC | 2 | 461 | 2.81 (1.41, 5.58) | <0.01 | Fixed | 0 | 0.45 | |
| 90dM | 3 | 7850 | 5.68 (1.32, 24.41) | 0.02 | Random | 53 | 0.12 | |