Table 1. Receiver operating characteristic curve of all parameters in the positive control, 10% propolis ointment-treated, ivermectin-treated, and propolis ointment/ivermectin combination-treated groups.

Parameters	Group	AUC	Cut-off value	Sensitivity	Specificity
Total protein (g/dl)	(+ve) Control	0.620	5.500	80.0%	40.0%
	10% propolis ointment	0.620	5.500	60.0%	60.0%
	ivermectin	0.880	6.500	60.0%	100.0%
	propolis + ivermectin	0.700	5.500	80.0%	60.0%
Albumin (g/dl)	(+ve) Control	0.700	3.500	60.0%	80.0%
	10% Propolis ointment	0.600	3.500	40.0%	80.0%
	ivermectin	0.600	3.500	100.0%	20.0%
	propolis + ivermectin	0.700	3.500	60.0%	80.0%
Globulin (g/dl)	(+ve) Control	0.820	2.500	40.0%	100.0%
	10% propolis ointment	0.720	2.500	40.0%	100.0%
	ivermectin	0.820	2.500	40.0%	100.0%
	propolis + ivermectin	0.560	3.000	20.0%	100.0%
ALP (IU/l)	(+ve) Control	1.000	57.500	100.0%	100.0%
	10% propolis ointment	1.000	56.000	100.0%	100.0%
	ivermectin	1.000	63.500	100.0%	100.0%
	propolis + ivermectin	1.000	69.500	100.0%	100.0%
AST (IU/l)	(+ve) Control	1.000	55.620	100.0%	100.0%
	10% propolis ointment	0.640	46.900	60.0%	80.0%
	ivermectin	1.000	45.295	100.0%	100.0%
	propolis + ivermectin	0.760	45.950	60.0%	100.0%
ALT (IU/l)	(+ve) control	0.920	48.405	80.0%	100.0%
	10% Propolis ointment	1.000	28.460	100.0%	100.0%
	ivermectin	1.000	27.870	100.0%	100.0%
	propolis + ivermectin	1.000	29.510	100.0%	100.0%
Serum cortisol (ng/ml)	(+ve) Control	1.000	3.930	100.0%	100.0%
	10% propolis ointment	1.000	2.195	100.0%	100.0%
	ivermectin	0.880	2.840	100.0%	80.0%
	propolis + ivermectin	1.000	2.190	100.0%	100.0%

AUC (area under the curve)

AUC = 0.5–0.65 (useless biomarker)

AUC = 0.7–0.85 (good biomarker)

AUC = 0.86–1 (with satisfactory sensitivity and specificity: excellent biomarker)