Table 2. Association between SNPs in miRNA processing genes and cervical precancerous lesions.
| SNP | Model | Polymorphism | Control (n=296) | Case (n=296) | OR3 (95% CI) | P-value3 |
|---|---|---|---|---|---|---|
| RANrs14035 | ||||||
| Codominant | CC | 186 | 192 | 1.00 (Ref) | ||
| CT | 95 | 93 | 0.88 (0.61–1.25) | 0.464 | ||
| TT | 15 | 10 | 0.69 (0.30–1.59) | 0.386 | ||
| Dominant | CT + TT | 110 | 103 | 0.85 (0.61–1.20) | 0.356 | |
| Recessive | CC + CT | 281 | 285 | 1.00 (Ref) | ||
| TT | 15 | 10 | 0.72 (0.32–1.65) | 0.440 | ||
| Allele | C | 467 | 477 | 1.00 (Ref) | ||
| T | 125 | 113 | 0.89 (0.67–1.18) | 0.400 | ||
| XPO5rs11077 | ||||||
| Codominant | TT | 268 | 257 | 1.00 (Ref) | ||
| TG | 27 | 37 | 1.58 (0.92–2.72) | 0.096 | ||
| GG | 1 | 2 | 1.75 (0.16–19.62) | 0.650 | ||
| Dominant | TG + GG | 28 | 39 | 1.59 (0.94–2.70) | 0.086 | |
| Recessive | TT + TG | 295 | 294 | 1.00 (Ref) | ||
| GG | 1 | 2 | 1.67 (0.15–18.67) | 0.678 | ||
| Allele | T | 563 | 551 | 1.00 (Ref) | ||
| G | 29 | 41 | 1.44 (0.89–2.36) | 0.139 | ||
| DICER1 rs3742330 | ||||||
| Codominant | AA | 90 | 134 | 1.00 (Ref) | ||
| AG | 161 | 117 | 0.51 (0.35–0.73) | <0.0012 | ||
| GG | 45 | 45 | 0.68 (0.41–1.12) | 0.134 | ||
| Dominant | AG + GG | 206 | 162 | 0.54(0.39–0.77) | 0.0011 | |
| Recessive | AA + AG | 251 | 251 | 1.00 (Ref) | ||
| GG | 45 | 45 | 1.00 (0.63–1.57) | 0.989 | ||
| Allele | A | 341 | 385 | 1.00 (Ref) | ||
| G | 251 | 207 | 0.73 (0.58–0.92) | 0.0091 | ||
| DICER1rs13078 | ||||||
| Codominant | TT | 282 | 280 | 1.00 (Ref) | ||
| TA | 14 | 15 | 1.05 (0.49–2.22) | 0.902 | ||
| Dominant | TA + AA | 14 | 15 | 1.05 (0.49–2.22) | 0.902 | |
| Allele | T | 578 | 575 | 1.00 (Ref) | ||
| A | 14 | 15 | 1.08 (0.52–2.25) | 0.844 |
Abbreviation: NA, not available.
1, P-value less than 0.05.
2, P-value less than 0.001.
Adjusted for age at first intercourse and number of pregnancies in logistic regression models.