Each mRNA expression of GINS subunit in tumor tissue was stratified into high or low expression using the median expression value as the cut-off point. Kaplan–Meier survival curves in male HCC patients for (A) GINS1 (High expression, n=123; Low expression, n=123), (B) GINS2 (High expression, n=123; Low expression, n=123), (C) GINS3 (High expression, n=124; Low expression, n=122), and (D) GINS4 (High expression, n=123; Low expression, n=123), or in female HCC patients for (E) GINS1 (High expression, n=59; Low expression, n=59), (F) GINS2 (High expression, n=59; Low expression, n=59), (G) GINS3 (High expression, n=60; Low expression, n=58), and (H) GINS4 (High expression, n=59; Low expression, n=59), and the corresponding P-value for Log-rank test were showed.