Table 2. Meta-analysis results of the association between UII gene rs228648 polymorphism and DM risk.
| Contrasts | Number of studies | OR [95%CI] | P | Heterogeneity | Effect model | |
|---|---|---|---|---|---|---|
| Ph | I2 | |||||
| AA+GA vs. GG | 5 | 0.70 [0.53, 0.91] | 0.007 | 0.12 | 45% | F |
| Chinese | 4 | 0.61 [0.46, 0.81] | 0.0006 | 0.91 | 0% | F |
| Non-Chinese | 1 | 2.67 [0.91, 7.84] | 0.07 | – | – | – |
| CDM | 3 | 0.87 [0.45, 1.68] | 0.67 | 0.04 | 69% | R |
| GDM | 2 | 0.58 [0.37, 0.91] | 0.02 | 0.59 | 0% | F |
| A vs. G | 7 | 0.68 [0.56, 0.82] | <0.001 | 0.07 | 48% | R |
| Chinese | 5 | 0.65 [0.56, 0.77] | <0.001 | 0.65 | 0% | F |
| Non-Chinese | 2 | 0.76 [0.38, 1.51] | 0.43 | 0.004 | 88% | R |
| CDM | 5 | 0.72 [0.57, 0.91] | 0.006 | 0.05 | 58% | R |
| GDM | 2 | 0.56 [0.42, 0.76] | 0.0002 | 0.97 | 0% | F |
| AA vs. GG | 5 | 0.41 [0.28, 0.61] | <0.001 | 0.31 | 16% | F |
| Chinese | 4 | 0.40 [0.27, 0.61] | <0.001 | 0.2 | 35% | F |
| Non-Chinese | 1 | 0.51 [0.15, 1.76] | 0.29 | – | – | – |
| CDM | 3 | 0.50 [0.30, 0.82] | 0.006 | 0.2 | 39% | F |
| GDM | 2 | 0.31 [0.17, 0.57] | 0.0002 | 0.74 | 0% | F |
| GA vs. GG | 5 | 0.90 [0.54, 1.51] | 0.7 | 0.02 | 65% | R |
| Chinese | 4 | 0.70 [0.52, 0.94] | 0.02 | 0.94 | 0% | F |
| Non-Chinese | 1 | 4.66 [1.58, 13.78] | 0.005 | – | – | – |
| CDM | 3 | 1.13 [0.45, 2.83] | 0.8 | 0.004 | 82% | R |
| GDM | 2 | 0.73 [0.45, 1.19] | 0.21 | 0.61 | 0% | F |
| AA vs. GA+GG | 5 | 0.36 [0.19, 0.71] | 0.003 | 0.002 | 76% | R |
| Chinese | 4 | 0.48 [0.33, 0.69] | <0.001 | 0.16 | 42% | F |
| Non-Chinese | 1 | 0.13 [0.06, 0.25] | <0.001 | – | – | – |
| CDM | 3 | 0.36 [0.11, 1.15] | 0.09 | <0.001 | 88% | R |
| GDM | 2 | 0.37 [0.21, 0.64] | 0.0004 | 0.98 | 0% | F |
Values in bold indicate a significant association. Abbreviations: CDM, common diabetes mellitus; GDM, gestational diabetes mellitus; OR, odd ratio; 95%CI, 95% confidence interval; F, fixed model; R, random model; Ph, P-value for the heterogeneity test.