Table 2. Results of overall and subgroup analyses.
| Population | Sample size | Dominant comparison | Recessive comparison | Additive comparison | Allele comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | P value | OR (95%CI) | I2 statistic | ||
| rs1801394 | |||||||||||||
| Overall | 4899/5246 | 0.0001 | 0.68 (0.56–0.83) | 72% | 0.009 | 1.40 (1.09–1.79) | 56% | 0.008 | 1.12 (1.03–1.21) | 48% | 0.0001 | 0.73 (0.63–0.86) | 77% |
| Caucasian | 887/1375 | 0.11 | 0.75 (0.52–1.07) | 68% | 0.18 | 1.45 (0.85–2.49) | 76% | 0.62 | 1.05 (0.87–1.26) | 0% | 0.10 | 0.75 (0.53–1.06) | 84% |
| Asian | 3675/3712 | 0.0008 | 0.60 (0.45–0.81) | 82% | 0.02 | 1.24 (1.04–1.48) | 34% | 0.006 | 1.43 (1.11–1.85) | 74% | 0.0007 | 0.69 (0.55–0.85) | 79% |
| VSD | 558/587 | <0.0001 | 0.55 (0.43–0.69) | 0% | <0.0001 | 2.22 (1.51–3.26) | 15% | 0.02 | 1.32 (1.04–1.66) | 0% | <0.0001 | 0.60 (0.51–0.72) | 0% |
| rs1532268 | |||||||||||||
| Overall | 1005/1098 | 0.001 | 0.56 (0.39–0.80) | 64% | 0.06 | 1.83 (0.96–3.48) | 68% | 0.0009 | 1.36 (1.13–1.63) | 23% | 0.0006 | 0.61 (0.47–0.81) | 68% |
| Caucasian | 223/225 | 0.08 | 0.44 (0.18–1.09) | 78% | <0.0001 | 2.93 (1.77–4.88) | 16% | 0.94 | 1.02 (0.70–1.48) | 0% | <0.0001 | 0.50 (0.38–0.66) | 46% |
| Asian | 782/873 | 0.008 | 0.64 (0.46–0.89) | 52% | 0.65 | 1.12 (0.69–1.80) | 29% | 0.0002 | 1.48 (1.21–1.83) | 0% | 0.0007 | 0.75 (0.63–0.88) | 33% |
| VSD | 306/326 | <0.0001 | 0.58 (0.42–0.79) | 0% | 0.11 | 2.48 (0.82–7.52) | 70% | 0.47 | 1.25 (0.68–2.28) | 71% | <0.0001 | 0.62 (0.49–0.79) | 0% |
| rs1801131 | |||||||||||||
| Overall | 2834/2761 | 0.44 | 0.93 (0.76–1.13) | 63% | 0.003 | 1.36 (1.11–1.67) | 42% | 0.88 | 0.99 (0.88–1.11) | 38% | 0.23 | 0.90 (0.75–1.07) | 72% |
| Caucasian | 905/1127 | 0.14 | 0.74 (0.49–1.10) | 78% | 0.01 | 1.40 (1.08–1.81) | 45% | 0.62 | 1.05 (0.87–1.26) | 43% | 0.10 | 0.77 (0.57–1.05) | 81% |
| Asian | 1300/1246 | 0.75 | 0.97 (0.82–1.15) | 23% | 0.009 | 1.78 (1.15–2.75) | 47% | 0.97 | 0.99 (0.74–1.34) | 55% | 0.42 | 0.89 (0.68–1.18) | 64% |
| VSD | 601/641 | 0.95 | 0.99 (0.79–1.25) | 21% | 0.74 | 1.12 (0.58–2.18) | 0% | 0.96 | 0.99 (0.78–1.26) | 44% | 0.88 | 0.98 (0.81–1.20) | 0% |
| rs1801133 | |||||||||||||
| Overall | 5508/6207 | <0.0001 | 0.73 (0.63–0.84) | 62% | <0.0001 | 1.54 (1.30–1.83) | 59% | 0.86 | 1.01 (0.93–1.09) | 86% | <0.0001 | 0.75 (0.67–0.84) | 73% |
| Caucasian | 1334/1749 | 0.02 | 0.83 (0.72–0.97) | 26% | 0.01 | 1.35 (1.06–1.72) | 28% | 0.42 | 1.06 (0.91–1.24) | 0% | 0.004 | 0.84 (0.75–0.95) | 50% |
| Asian | 3485/3764 | <0.0001 | 0.67 (0.55–0.83) | 73% | <0.0001 | 1.66 (1.32–2.10) | 71% | 0.43 | 0.96 (0.87–1.06) | 48% | <0.0001 | 0.70 (0.60–0.83) | 81% |
| TOF | 701/764 | 0.0001 | 0.63 (0.50–0.80) | 48% | <0.0001 | 2.17 (1.66–2.84) | 0% | 0.28 | 0.89 (0.71–1.10) | 0% | <0.0001 | 0.62 (0.53–0.72) | 4% |
| VSD | 754/788 | 0.48 | 0.85 (0.54–1.33) | 68% | 0.37 | 1.43 (0.65–3.14) | 75% | 0.90 | 0.99 (0.81–1.21) | 0% | 0.36 | 0.82 (0.54–1.25) | 80% |
Abbreviations: ASD, atrial septal defect; CHD, congenital heart disease; CI, confidence interval; NA, not available; OR, odds ratio; PDA, patent ductus arteriosus; TOF, tetralogy of fallot; VSD, ventricular septal defect.
The values in bold represent there is statistically significant differences between cases and controls.