Table 3. Distributions of CACNA 1A, CACNA 1C, and CACNA 1H genotypes and alleles in the DPN, non-DPN, and control groups.
| Genotype | DPN group (%) | Non-DPN group (%) | Control group (%) | P* | OR (95% CI) | P† | OR (95% CI) | P‡ | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| CACNA 1A | |||||||||
| rs2248069 | |||||||||
| AA | 32 (22.4) | 50 (36.2) | 80 (44.4) | 1 | 1 | 1 | |||
| GA | 68 (47.5) | 72 (52.2) | 87 (48.3) | 0.012 | 1.95 (1.16, 3.28) | 0.168 | 1.48 (0.85, 2.57) | 0.243 | 1.32 (0.83, 2.12) |
| GG | 43 (30.1) | 16 (11.6) | 13 (7.3) | <0.001 | 8.27 (3.93, 17.40) | <0.001 | 4.20 (2.03, 8.68) | 0.1 | 1.97 (0.87, 4.44) |
| GA + AA | 111 (77.6) | 88 (63.8) | 100 (55.6) | <0.001 | 2.78 (1.70, 4.54) | 0.012 | 1.97 (1.17, 3.33) | 0.14 | 1.41 (0.89, 2.22) |
| A | 132 (46.2) | 172 (62.3) | 247 (68.6) | 1 | 1 | 1 | |||
| G | 154 (53.8) | 104 (37.7) | 113 (31.4) | <0.001 | 2.55 (1.85, 3.52) | <0.001 | 1.93 (1.38, 2.70) | 0.097 | 1.32 (0.95, 1.84) |
| rsl6030 | |||||||||
| CC | 80 (55.9) | 85 (61.6) | 125 (66.7) | 1 | 1 | 1 | |||
| CT | 27 (18.9) | 35 (25.4) | 46 (28.3) | 0.759 | 0.92 (0.53, 1.59) | 0.507 | 0.82 (0.46, 1.48) | 0.671 | 1.12 (0.67, 1.88) |
| TT | 36 (25.2) | 18 (13.0) | 9 (5.0) | <0.001 | 6.25 (2.86, 13.67) | 0.026 | 2.07 (1.08, 3.94) | 0.01 | 2.94 (1.26, 6.86) |
| CT + TT | 63 (44.1) | 53 (38.4) | 60 (33.3) | 0.012 | 1.79 (1.13, 2.83) | 0.336 | 1.26 (0.78, 2.03) | 0.143 | 1.42 (0.89, 2.26) |
| C | 187 (65.4) | 205 (74.3) | 291 (80.8) | 1 | 1 | 1 | |||
| T | 99 (34.6) | 71 (25.7) | 69 (19.2) | <0.001 | 2.45 (1.70, 3.52) | 0.022 | 1.53(1.06, 2.20) | 0.015 | 1.60(1.09, 2.35) |
| CACNA 1C | |||||||||
| rs216008 | |||||||||
| CC | 54 (37.8) | 69 (50.0) | 110 (61.1) | 1 | 1 | 1 | |||
| CT | 51 (35.6) | 38 (27.5) | 40 (22.2) | <0.001 | 2.60 (1.53, 4.40) | 0.054 | 1.72 (0.99, 2.98) | 0.128 | 1.51(0.89,2.59) |
| TT | 38 (26.6) | 31 (22.5) | 30 (16.7) | 0.001 | 2.58 (1.45, 4.60) | 0.137 | 1.57 (0.86, 2.84) | 0.093 | 1.65(0.92,2.96) |
| CT + TT | 89 (62.2) | 69 (50.0) | 70 (38.9) | <0.001 | 2.59 (1.65, 4.07) | 0.039 | 1.65 (1.03, 2.65) | 0.048 | 1.57(1.00,2.46) |
| C | 159 (55.6) | 176 (63.8) | 260 (72.2) | 1 | 1 | 1 | |||
| T | 127 (44.4) | 100 (36.2) | 100 (27.8) | <0.001 | 2.08 (1.50, 2.88) | 0.048 | 1.41(1.00, 1.97) | 0.023 | 1.48(1.06,2.07) |
| rs2239050 | |||||||||
| GG | 67 (46.9) | 82 (59.4) | 115 (63.9) | 1 | 1 | 1 | |||
| GC | 48 (33.5) | 46 (33.3) | 57 (31.7) | 0.138 | 1.45 (0.89, 2.36) | 0.354 | 1.28 (0.76, 2.14) | 0.614 | 1.13 (0.70, 1.83) |
| CC | 28 (19.6) | 10 (7.3) | 8 (4.4) | <0.001 | 6.01 (2.59, 13.94) | 0.002 | 3.43 (1.55, 7.56) | 0.253 | 1.75 (0.66, 4.63) |
| GC + CC | 76 (53.1) | 56 (40.6) | 65 (36.1) | 0.002 | 2.01 (1.28, 3.14) | 0.035 | 1.66 (1.04, 2.67) | 0.416 | 1.21 (0.77, 1.91) |
| G | 182 (63.6) | 210 (76.1) | 287 (79.7) | 1 | 1 | 1 | |||
| C | 104 (36.4) | 66 (23.9) | 73 (20.3) | <0.001 | 2.25 (1.58, 3.20) | 0.001 | 1.82 (1.26, 2.62) | 0.272 | 1.24 (0.85, 1.80) |
| CACNA 1H | |||||||||
| rs3794619 | |||||||||
| TT | 64 (44.8) | 93 (67.4) | 120 (66.7) | 1 | 1 | 1 | |||
| TC | 55 (38.4) | 32 (23.2) | 41 (22.8) | <0.001 | 2.52 (1.52, 4.17) | <0.001 | 3.48 (1.94, 6.22) | 0.979 | 1.01 (0.59, 1.72) |
| CC | 24 (16.8) | 13 (9.4) | 19 (10.6) | 0.011 | 2.37 (1.21, 4.65) | 0.001 | 2.68 (1.27, 5.66) | 0.747 | 0.88 (0.41, 1.88) |
| TC + CC | 79 (55.2) | 45 (32.6) | 60 (33.3) | <0.001 | 2.47 (1.57, 3.88) | <0.001 | 2.55 (1.57, 4.14) | 0.892 | 0.97 (0.60, 1.55) |
| T | 183 (64.0) | 218 (79.0) | 281 (78.1) | 1 | 1 | 1 | |||
| C | 103 (36.0) | 58 (21.0) | 79 (21.9) | <0.001 | 2.00 (1.42, 2.83) | <0.001 | 2.12 (1.45, 3.09) | 0.777 | 0.95 (0.65, 1.39) |
| rs7191246 | |||||||||
| GG | 83 (58.0) | 106 (76.8) | 143 (79.4) | 1 | 1 | 1 | |||
| GC | 30 (21.0) | 21 (15.2) | 30 (16.7) | 0.062 | 1.72 (0.97, 3.06) | 0.058 | 1.82 (0.97, 3.42) | 0.854 | 0.94 (0.51, 1.74) |
| CC | 30 (21.0) | 11 (8.0) | 7 (3.9) | <0.001 | 7.38 (3.11, 17.56) | 0.001 | 3.48 (1.65, 7.36) | 0.126 | 2.12 (0.80, 5.65) |
| GC + CC | 60 (42.0) | 32 (23.2) | 37 (20.6) | <0.001 | 2.79 (1.71, 4.57) | 0.001 | 2.40 (1.43, 4.01) | 0.572 | 1.17 (0.68, 1.99) |
| G | 196 (68.5) | 233 (84.4) | 316 (87.8) | 1 | 1 | 1 | |||
| C | 90 (31.5) | 43 (15.6) | 44 (12.2) | <0.001 | 3.30 (2.21, 4.93) | <0.001 | 2.49 (1.65, 3.75) | 0.222 | 1.33 (0.84, 2.09) |
*, compared with the DPN group and the control group P<0.05.
†, compared with the non-DPN group P<0.05.
‡, compared with the non-DPN group and the control group P<0.05.