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The dual-luciferase assay was performed to evaluate VEGF promoter activity. Cells were grown in conditions of normoxia (DFO-) or hypoxia (DFO+) for 24 h. The HIF2 N203H mutation significantly affected HIF2-mediated VEGF transcription, especially in conditions of hypoxia. ***p<0.001 vs. empty vector; #p<0.05; ###p<0.001 vs. wild-type (Student’s t-test).
