FIGURE 6.

Molecular docking of zafirlukast to human PPARγ and sEH. (A) Proposed binding mode of zafirlukast (gray sticks) to the PPARγ ligand binding domain – the acidic acyl sulphonamide moiety exhibits directed indications toward the amino acids responsible for activation of PPARγ, while the substituted indole residue occupies a large hydrophobic sub-pocket. (B) Proposed binding mode of zafirlukast (gray sticks) to the sEH C-terminal domain – the carbamate moiety interacts with the catalytic triade Tyr383, Tyr466 and Asp335.