Figure 1.

Study design. 6–8 weeks old female BALB/c mice were infected with HSV-2 or mock infected in the presence or absence of ZOTEN. At 2 and 4 days post infection (dpi), mice genitals were swabbed to detect viral shedding using a plaque assay. At 7 dpi, mice were euthanized, and vaginal tissues were extracted and analyzed by histology, flow cytometry, and quantitative PCR (qPCR) to appreciate differences in cellular infiltration and local inflammation.