Figure 1.

Schematic diagrams summarizing diverse functions of NFAT5 in macrophages and T lymphocytes in response to high salt conditions and signaling through different receptors (please see main text for more detailed description and references). Upward- and downward-pointing arrows indicate NFAT5-activated or –repressed functions respectively. ^*The balance between naïve and memory T cells has been shown in vivo in steady state conditions in NFAT5-null mice and in vitro under conditions of homeostatic T cell maintenance with IL-7, not with T cell receptor simulation.