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. 2019 Mar 20;10:207. doi: 10.3389/fphar.2019.00207

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Copyright © 2019 Micale, Drago, Noerregaard, Elling and Wotjak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of systemic rimonabant treatment on the expression of auditory-cued fear memory. Freezing responses (mean ± S.E.M.) of the animals after per os (RIM: 0, 3, or 10 mg/kg) or subcutaneous rimonabant (RIM: 3 mg/kg) treatment before re-exposure to the 3 min tone at days 1–3 after conditioning (day 0) averaged over the entire 180 s tone presentation (upper right) or in 20-s interval (lower panel). n = 11–13 mice per group. Data were analyzed by two-way ANOVAs for repeated measurements. Newman-Keuls post-hoc comparisons for the main effects Treatment are indicated above the graphs. For the matter of clarity, we do not report post-hoc results in case of factorial interactions.