. 2019 Mar 26;4:7. doi: 10.1038/s41536-019-0066-7

Table 1.

Pairwise comparison using Fisher’s protected LSD analysis of all HD mice

	Treatment 1	Treatment 2	95% Confidence intervals		P-value
	Treatment 1	Treatment 2	Lower	Upper	P-value
Rotarod	Sham	WT-NPC	−0.0347	−0.0003	0.0468*
		HD-shHD-NPC	−0.0375	−0.0087	0.0026*
		HD-NPC	−0.0352	0.0242	0.7103
	HD-NPC	WT-NPC	−0.0183	0.0423	0.4297
	HD-NPC	HD-shHD-NPC	−0.0123	0.0474	0.2422
	HD-shHD-NPC	WT-NPC	−0.0176	0.0064	0.3479
Grip strength	Sham	WT-NPC	−0.0762	−0.0201	0.0014*
		HD-shHD-NPC	−0.0750	−0.0124	0.0077*
		HD-NPC	−0.0550	0.0290	0.5356
	HD-NPC	WT-NPC	−0.0042	0.0745	0.0785
	HD-NPC	HD-shHD-NPC	−0.0129	0.0743	0.1629
	HD-shHD-NPC	WT-NPC	−0.0158	0.0247	0.6563

Rotarod and grip strength tests of HD mice with different treatments were compared using Fisher’s protected LSD test implemented post-hoc on linear regressions to identify differences. For rotarod, HD mice that received intrastriatal WT-NPC injection showed significant improvement compared to the sham injection group (P = 0.0468), and mice that received intrastriatal HD-shHD-NPC showed considerable improvement (P = 0.0026). For grip strength, HD mice that received intrastriatal WT-NPC and HD-shHD-NPC injection showed significant improvement compared to the sham injection group (P = 0.0014, P = 0.0077, respectively) (* denotes P < 0.05)