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. 2019 Mar 26;9:5148. doi: 10.1038/s41598-019-41685-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dis inhabits cell proliferation through G2/M arrest. (A) Cell proliferation of HCT-116 was performed in the absence and presence of Dis at various time points (24 h, 48 h and 72 h) using flow cytometry. Figure demonstrates that cells were arrested in G2/M phase. (B) Quantitative analysis demonstrated that cells were arrested in G2/M phase. Data were expressed as mean ± standard deviation. *p < 0.5, ***p < 0.001, ****p < 0.0001 indicate significant differences compared to control.