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. 2019 Mar 26;9:5116. doi: 10.1038/s41598-019-41414-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan and Meier survival plot for the wild-type (WT), heterozygous (HTZ) and McArdle (McA) mice born between 01/01/2013 and 05/08/2018. There was a significant reduction in the survival rate of McA with respect HTZ and WT [p < 0.0001; log-rank (Mantel-Cox test)]. From 464 WT, 461 were censored and 3 spontaneous deaths (events) occurred in 831 days; from 1435 HTZ, 1420 were censored and 15 events occurred in 1012 days; finally, from 189 McA, 137 were censored and 52 events occurred in 997 days.