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. 2019 Mar 26;9:5116. doi: 10.1038/s41598-019-41414-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological characterization of McArdle mice. (A) H&E staining of the soleus, gastrocnemius, extensor digitorum longus (EDL), tibialis anterior (TA) and quadriceps muscles from 8-week-old wild-type (WT) and heterozygous (HTZ) and 8, 35 and 70-week-old McArdle (McA) mice. All scale bars correspond to 75 µm. (B) Laminin-DAPI, Col IV-DAPI and FBN-DAPI stains of TA muscles from 8, 35 and 70-week-old McA and 70-week-old WT. All scale bars correspond to 150 µm. (C) Tone modified (Adobe^® Photoshop^® tone and saturation adjustments were set at −105 and +25, respectively) laminin-DAPI stain of soleus and TA muscles from 70-week-old WT and 8, 35 and 70-week-old McA. Due to the tone modification laminin staining has become dark blue, whereas DAPI staining has become light blue/green and nuclei are much more highlighted. All scale bars correspond to 150 µm. (D) CD68 (pan-macrophage marker)-DAPI staining of TA from 70-week-old McA and CD68, Col IV and DAPI stains of quadriceps from 70-week-old McA mice.