Table 5.
Comparison of gene expression pattern following an increase of cAMP levels in granulosa cells with that in previous reports.
| Feature ID | Annotations - database object name | Khan et al., 2015 | Present data | Experiment – fold change* (original values) | Kal’s Z-test: P-value correction | Number of mapped reads before FSK and IBMX treatment | Number of mapped reads after FSK and IBMX treatment |
|---|---|---|---|---|---|---|---|
| HK2 | Protein-histidine pros-kinase | upregulated | upregulated | 13.31469649 | 0 | 626 | 8,335 |
| SLC2A13 | Solute carrier family 2, facilitated glucose transporter member 13 | not assessed | upregulated | 3.9333333 | 3.05E-09 | 15 | 59 |
| SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | upregulated | upregulated | 3.9316843 | 0 | 3,396 | 13,352 |
| SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 | not assessed | unchanged | 3 | 0.149116134 | 2 | 6 |
| SLC2A3 | Solute carrier family 2, facilitated glucose transporter member 3 | unchanged | upregulated | 2.8121891 | 0 | 19,903 | 55,971 |
| SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 | not assessed | upregulated | 2.6663466 | 0 | 2,083 | 5,554 |
| FSHR | Follicle-stimulating hormone receptor | unchanged | upregulated | 2.59792 | 0 | 1,925 | 5,001 |
| PGR | Progesterone receptor | upregulated | upregulated | 2.58333 | 1.35E-15 | 60 | 155 |
| SLC2A12 | Solute carrier family 2, facilitated glucose transporter member 12 | not assessed | upregulated | 2.4375 | 6.86E-08 | 32 | 78 |
| SLC2A10 | Solute carrier family 2, facilitated glucose transporter member 10 | not assessed | upregulated | 2.3035714 | 1.59E-11 | 56 | 129 |
| NR4A1 | Nuclear receptor subfamily 4 group A member 1 | upregulated | upregulated | 2.19731 | 0 | 10,471 | 23,008 |
| AKT2 | v-Akt murine thymoma viral oncogene homologue 2 | down | upregulated | 1.47771 | 0 | 875 | 1,293 |
| TP53 | Cellular tumor antigen p53 | downregulated | upregulated | 1.33214 | 0 | 557 | 742 |
| PDGFB | PDGFB protein | unchanged | unchanged | 1.08451 | 0.122965 | 71 | 77 |
| SLC2A2 | Solute carrier family 2, facilitated glucose transporter member 2 | not assessed | unchanged | 1 | 1 | 0 | 0 |
| AREG | Amphiregulin | upregulated | unchanged | −1 | 1 | 1 | 1 |
| MAP2K3 | Mitogen-activated protein kinase 3 | upregulated | downregulated | −1.3971 | 0.000806 | 2,255 | 1,614 |
| EGR1 | Early growth response protein 1 | downregulated | downregulated | −1.64276228 | 0 | 25,977 | 15,813 |
| HAS2 | Hyaluronan synthase 2 | upregulated | unchanged | −1.8 | 0.10881 | 72 | 40 |
| CCK | Cholecystokinin | upregulated | unchanged | −1.8333 | 0.447261 | 22 | 12 |
| DUSP1 | Dual-specificity protein phosphatase | downregulated | downregulated | −3.523 | 0 | 2,371 | 673 |
| ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide | unchanged | downregulated | −3.5385 | 0.001078 | 46 | 13 |
| GFPT2 | Glutamine-fructose-6-phosphate transaminase 2 | upregulated | downregulated | −4.54113924 | 0 | 1,435 | 316 |
| STAR | Steroidogenic acute regulatory protein, mitochondrial | upregulated | downregulated | −37.4455 | 0 | 11,346 | 303 |
*When the ratio is less than 1, it is converted to its negative inverse.
The transcriptome data have been deposited in the DDBJ Sequence Read Archive (DRA) with accession number DRA006403.
Bold show upregulated. Italic show downregulated.