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. 2019 Mar 26;9:5143. doi: 10.1038/s41598-019-41597-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in the relative abundance of the five most common genera with age in infants with CF. Figure shows the mean relative abundance of Streptococcus spp., Haemophilus spp., Neisseria spp., Veillonella spp. and Granulicatella spp. using a proportional scale where all samples have been rarefied to 600 reads. The error bars represent the standard deviation. An inverse relationship in the relative abundance of Streptococcus spp. and Haemophilus spp. in the first two years of life is observed.