Table 2.

Summary of genus level changes for 5 most common organisms with age.

Organism	Age range (in months)	Estimate	z-value	SE	P-value
Streptococcus	7–8	0.77	3.6	0.22	<0.001
Haemophilus	9–10	−1.1	−2.1	0.50	0.034
Veillonella	2	−1.5	−3.5	0.44	<0.001
Neisseria	7–8	−1.6	−2.9	0.57	0.004
Granulicatella	19–21	2.3	3.7	0.62	<0.001

Shown above is the age range for each of the most common organisms at which the greatest change in relative abundance was seen using a non-linear mixed effects model using a negative binomial error structure controlling for patient. The model fits changes in abundance using a log scale. The mean change in relative abundance from baseline is shown by the “Estimate”. The z-value indicates the number of standard deviations of the estimate from the mean relative abundance at baseline. SE – standard error.