Table 1.
Blood gas analysis. Blood gas analysis performed on mixed arterial-venous blood samples obtained by cardiac puncture immediately after sacrifice.
| Parameter | Denervation (group A) | Sham (group B) | Hypoxia (group C) | Normoxia (group D) | P-value |
|---|---|---|---|---|---|
| (N = 8) | (N = 9) | (N = 8) | (N = 8) | ||
| Oxygenation | |||||
| PO2 (mmHg) | 107 ± 18& | 80 ± 14 | 49 ± 5 | 62 ± 7 | 0.005 |
| sO2 (%) | 90 ± 2 | 84 ± 5 | 65 ± 6** | 82 ± 4 | 0.011 |
| ctO2 (vol-%) | 21 ± 1*** | 15 ± 1 | 13 ± 1 | 15 ± 1 | <0.001 |
| Hct (%) | 52 ± 1* | 40 ± 2 | 43 ± 1 | 40 ± 1 | <0.001 |
| ctHb (g·dL−1) | 17 ± 0*** | 13 ± 1 | 14 ± 0 | 13 ± 0 | <0.001 |
| Acid-base homeostasis | |||||
| pH | 7.01 ± 0.03* | 7.21 ± 0.02 | 7.11 ± 0.03* | 7.24 ± 0.01 | <0.001 |
| PCO2 (mmHg) | 84 ± 5* | 51 ± 5 | 70 ± 5 | 59 ± 1 | 0.003 |
| ctCO2 (mmol·L−1) | 19 ± 1 | 18 ± 1 | 20 ± 1 | 23 ± 1** | 0.001 |
| cHCO3− (mmol·L−1) | 20 ± 1 | 19 ± 1 | 21 ± 1 | 24 ± 1*** | <0.001 |
| BE (mmol·L−1) | −15 ± 1*** | −9 ± 1 | −10 ± 1 | −4 ± 1*** | <0.001 |
| Anion gap (mmol·L−1) | 24 ± 1 | 25 ± 1 | 26 ± 1 | 23 ± 1& | 0.012 |
| Electrolytes | |||||
| cNa+ (mmol·L−1) | 150 ± 1 | 150 ± 1 | 152 ± 1 | 152 ± 0 | 0.104 |
| cK+ (mmol·L−1) | 4.0 ± 0.2&& | 3.7 ± 0.1 | 3.4 ± 0.1 | 3.4 ± 0.1 | 0.015 |
| cCa2+ (mmol·L−1) | 1.2 ± 0.1 | 1.1 ± 0.0 | 1.0 ± 0.1 | 1.1 ± 0.1 | 0.191 |
| cCl− (mmol·L−1) | 110 ± 1 | 111 ± 1 | 109 ± 1 | 108 ± 1 | 0.076 |
Statistically significant * vs. sham and normoxia; **vs. denervation and sham; ***vs. all other groups; &vs. the hypoxia group; &&vs. hypoxia and normoxia. All statistically significant values are marked in boldface.
Abbreviations: Partial oxygen pressure (PO2), oxygen saturation (sO2), oxygen content (ctO2), hematocrit (Hct), hemoglobin content (ctHb), partial carbon dioxide pressure (PCO2), carbon dioxide content (ctCO2), bicarbonate concentration (cHCO3−), base excess (BE), sodium concentration (cNa+), potassium concentration (cK+), calcium concentration (cCa2+), chloride concentration (cCl−).