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. 2019 Mar 26;9(4):39. doi: 10.1038/s41408-019-0199-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CNA timing interval in HMM (a) and NHMM (b) are calculated with bootstrap with 1000 iterations using the R v (3.3.2) package boot. Timing on the x-axis is from early to late, early being 1 and late being 4 on clonality score. Red squares show the mean timing for each event (y-axis). Horizontal bars indicate 90% bootstrap confidence interval of the mean