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. 2019 Mar 26;9:5165. doi: 10.1038/s41598-019-41621-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Association between elimination of CCR7 and behaviour of MSCs in vitro. (A) The effect of CCL21 (100 ng/ml) on cell migration (n = 10/group). All values are expressed as mean ± SD. *P < 0.05, statistically significant (ANOVA followed by Tukey’s post hoc test). (B) The effect of CCL21 (100 ng/ml) on cell proliferation (n = 10/group at each time point). All values are expressed as mean ± SD. (C) MSCs were differentiated in chondrogenic medium by micromass culture. qRT-PCR analysis of gene expression during the chondrogenic differentiation process (n = 3/each group at each time point). All values are expressed as mean ± SD. *P < 0.05, statistically significant (ANOVA followed by Tukey’s post hoc test).