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. 2019 Mar 26;9:5165. doi: 10.1038/s41598-019-41621-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CCL21 does not inhibit subchondral bone repair. (A) Evaluation of subchondral bone repair by micro-CT. The cylindrical defect area was assessed as the ROI. (B) Representative 3D-CT images at 16 weeks postoperatively from each group (n = 10/group). (C,D) Repaired subchondral BV was assessed at 4 and 16 weeks postoperatively. All values are expressed as mean ± SD (n = 10/group). *P < 0.05, statistically significant (ANOVA followed by Tukey’s post hoc test).