. 2019 Mar 26;9:5174. doi: 10.1038/s41598-019-41595-2

Table 3.

Results of Cox regression analysis on all MIBC patients stratified into three groups (II, III and IV) using the standard TNM staging and the proposed model respectively, with their respective stage II as reference.

Model	Cox regression			Likelihood ratio test	Wald test	Log rank test
Model	Factor	HR [95% CI]	p value/q value	Likelihood ratio test	Wald test	Log rank test
Clinical TNM staging	Stage III	1.92 [0.82 4.51]	0.13	G = 34.1 p = 3.94E⁻⁰⁸	z^2 =36.2 p = 1.41E⁻⁰⁸	lr = 44.95 p = 1.74E⁻¹⁰
Clinical TNM staging	Stage IV	8.66 [3.65 20.28]	8.4E⁻⁰⁷**	G = 34.1 p = 3.94E⁻⁰⁸	z^2 =36.2 p = 1.41E⁻⁰⁸	lr = 44.95 p = 1.74E⁻¹⁰
TB stage model	Stage III	2.48 [1.18 5.21]	*0.017/0.119**	G = 36.9 p = 9.78E⁻⁰⁹ q = 6.85E⁻⁰⁸	z^2 =37.83 p = 6.09E⁻⁰⁹ q = 4.26E⁻⁰⁸	lr = 47.35 p = 5.22E⁻¹¹ q = 3.65E⁻¹⁰
TB stage model	Stage IV	7.33 [3.87 13.89]	1.0E⁻⁰⁹**/7.0E⁻⁰⁹	G = 36.9 p = 9.78E⁻⁰⁹ q = 6.85E⁻⁰⁸	z^2 =37.83 p = 6.09E⁻⁰⁹ q = 4.26E⁻⁰⁸	lr = 47.35 p = 5.22E⁻¹¹ q = 3.65E⁻¹⁰

Two degrees of freedom are considered for overall tests. P values of the TB stage model are corrected (q values) for multiple hypothesis testing corresponding to the (m = 7) features used for TB quantification.