Figure 8.

Models of HIV-1 Rev 5–83 and potential interactions of Rev hexamers with a Crm1 dimer. (A) Model of HIV-1 Rev 5–83 built using Chimera. (B) Model of a Crm1 dimer bound to Rev NES (from³³) (C) Three representative Rev hexamers generated using Rev 5–83 and dimerization and oligomerization surfaces (as in¹⁵). Rev subunits are colored from blue (subunit 1) to red (subunit 6). Different Rev NES sequences were aligned with one of the Crm1-bound Rev-NES peptide: NES1 from the first panel, NES6 from the second and NES 1 from the third panel. We then observed which other Rev NES sequences were in close proximity to the second Crm1-bound Rev-NES peptide.