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. 2019 Mar 26;9:5204. doi: 10.1038/s41598-019-41692-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Venn diagram showing the overlap of genes differentially expressed (from the 3,987 investigated) associated with the different eQTL types (cis, trans and modified). The numbers represent the number of genes differentially expressed associated with the different types of eQTLs: cis-eQTLs, SNPs in promoter regions, transcriptional start sites (TSS), upstream (up to −200 bp) or within the gene; tr-eQTLs, potentially impairing non-synonymous SNPs located in transcriptional regulators; and mod-eQTLs, methylated bases located either within the gene or upstream including promoter regions and TSS.