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. 2019 Mar 26;9:5220. doi: 10.1038/s41598-019-41593-4

Table 2.

Summary of the observations made on the influence of demographical factors.

Demographical considerations Group N In accordance with previous works
NcirDNA concentration
A statistical difference between males and females Healthy 104 Catarino R, et al.63
No statistical difference between males and females mCRC 118 Hao TB, et al.31
A statistical difference with regard to age Healthy 104 Jylhävä J, et al.35
No statistical difference with regard to age mCRC 118 Van der Drift MA, et al.30
Statistical increase in mCRC patients as compared to healthy individuals Healthy
mCRC		 104
118		 Bedin C, et al.64
McirDNA concentration
No statistical difference between males and females Healthy
mCRC		 104
50		 New observation
No statistical difference with regard to age Healthy
mCRC		 104
50		 Jylhävä J, et al.35
New observation
Statistical decrease in mCRC patients as compared to healthy individuals Healthy
mCRC		 104
50		 New observation
McirDNA vs NcirDNA concentration
Necessity of independently quantifying NcirDNA and McirDNA
About 50,000-fold more McirDNA copy number as compared to NcirDNA in healthy individuals Healthy 104 New observation
About 3,000-fold more McirDNA copy number as compared to NcirDNA in cancer patients mCRC 50 New observation
About 20-fold more McirDNA/NcirDNA ratio in healthy individuals as compared to mCRC patients Healthy
mCRC		 104
50		 New observation