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. 2019 Mar 26;9:5210. doi: 10.1038/s41598-019-41569-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of utrophin mechanical behavior. (a) Comparison of modes of the unfolding force distributions vs unfolding event count shows brittle vs stiffening behavior of utrophin constructs. Peak (or mode) of the distribution of unfolding forces expressed as a function of the number of domains unfolded (unfolding event count). Data are combined over 3 batches of 300–500 successful pulling experiments per batch for each protein construct and more detailed statistics are provided in Supplemental Fig. S11. (b) KS metrics for the distributions of unfolding force corresponding to different unfolding event counts from each of the utrophin constructs. The KS metrics are computed by using the force distribution of the first unfolding event of Utr NT-R10 as the reference distribution.