Table 1.
Properties of whole-cell recordings in mice granule cells
| WT (n = 92) | KO (n = 76) | |
|---|---|---|
| Rm (GΩ) | 2.0 ± 0.1 | 2.7 ± 0.2* |
| Cm (pF) | 3.6 ± 0.1 | 3.2 ± 0.1*** |
| Rs (MΩ) | 17.6 ± 1.1 | 18.3 ± 1.0 |
| fVC (KHz) | 3.5 ± 0.2 | 3.2 ± 0.2 |
| Vm (mV) | −50.2 ± 1.4 (n = 34) | −49.2 ± 1.5 (n = 30) |
Vm, Membrane potential. The data were obtained using K-gluconate intracellular solution and analyzing current transient elicited by 10 mV voltage-clamp steps delivered from the holding potential of −70 mV. The number of observations indicated and statistical significance are reported compared with IB2 KO granule cells.
*p < 0.05;
***p < 0.001, unpaired t test.