Table 2. The mutation patterns of the katG and inhA genes in 206 patients with a genotypic INH resistance.
| Group | INH mono-resistance | MDR-TB | Total | p-value |
|---|---|---|---|---|
| No. of subjects | 93 (45.1) | 113 (54.9) | 206 (100) | |
| katG mutation alone | 55 (59.1) | 79 (69.9) | 134 (65.0) | 0.107 |
| Mutant probe (+) | 50 (53.8) | 77 (68.1) | 127 (61.7) | 0.035 |
| Wild-type band loss alone | 5 (5.4) | 2 (1.8) | 7 (3.4) | 0.248 |
| inhA mutation alone (%) | 37 (39.8) | 29 (25.7) | 66 (32.0) | 0.031 |
| Mutant probe (+) | 33 (35.5) | 29 (25.7) | 62 (30.1) | 0.126 |
| Wild-type band loss alone | 4 (4.3) | 0 (0) | 4 (1.9) | 0.040 |
| Both gene mutation | 1 (1.1) | 5 (4.4) | 6 (2.9) | 0.225 |
| katG (MUT1), inhA (MUT1) | 0 (0) | 2 (1.8) | 2 (1.0) | |
| katG (MUT1), inhA (WT1 loss) | 1 (1.1) | 0 (0) | 1 (0.5) | |
| katG (MUT1), inhA (WT2 loss) | 0 (0) | 1 (0.9) | 1 (0.5) | |
| katG (WT loss), inhA (MUT1) | 0 (0) | 1 (0.9) | 1 (0.5) | |
| katG (WT loss), inhA (WT2 loss) | 0 (0) | 1 (0.9) | 1 (0.5) |
Values are presented as number (%).
INH: isoniazid; MDR-TB: multidrug-resistant tuberculosis; katG WT: S315 region; katG MUT1: S315T[AGC315ACC]; inhA WT1: positions −15 to −16; inhA WT2: positions −8; inhA MUT1: C15T.