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. 2018 Oct 28;155(3):587–594. doi: 10.1016/j.chest.2018.10.022

Figure 2.

Figure 2

Proposed molecular Wnt signaling pathway in lung fibrosis during ARDS. Wnt signaling begins when a Wnt protein binds to a Frizzled family receptor. To facilitate Wnt signaling, coreceptors such as lipoprotein receptor-related protein (LRP) and others may be required. On activation of the receptor, Axin is removed from the receptor complex and activates β-catenin. β-Catenin moves into the nucleus, binds to a transcription factor on DNA, and activates transcription of target genes. Wnt = wingless-related integration site.