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. 2019 Mar 22;3(6):922–933. doi: 10.1182/bloodadvances.2018026989

Figure 2.

Figure 2.

Variant allele frequencies (VAFs) of identified mutations in patients with NPM1-mutated MDS and MDS/MPN. Clonal composition, including the VAF of each individual driver mutation, identified within patients with NPM1-mutated MDS and MDS/MPN with available NGS data and ≥1 additional detectable mutation. Median VAF of NPM1 mutations is 0.38 (range, 0.09-0.49), with NPM1 mutations appearing in major clones in all patients with the exception of UPN 4, UPN 22, and UPN 25, as observed. *Patient had normal karyotype by conventional karyotyping.