FIG. 2.

Immune response to scaffolds is dominated by CD11b⁺ macrophages communicating with CD3⁺ T cells. (A) Immunohistochemical staining of the dorsal (skin) interface of the implant for CD11b⁺ macrophages, CD11c⁺ dendritic cells, and CD3⁺ T cells. (B) Cellular aggregates present at the dorsal interface stain positive for CD11b and CD3, but exclude CD11c. (C) Colocalization of CD11b⁺ macrophages and CD3⁺ T cells suggests an increased communication between macrophages and T cells as opposed to canonical CD11c⁺ dendritic cells. Scale bars = 200 μm.