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. 2017 Oct 1;23(19-20):1044–1053. doi: 10.1089/ten.tea.2016.0304

FIG. 6.

FIG. 6.

Detailed profile of myeloid cells in a scaffold-treated volumetric muscle wound. (A) A 3 × 4 mm portion of the quadriceps muscle is excised and replaced with a biomaterial scaffold: Saline vehicle control, Collagen, B-ECM (decalcified bone ECM), and C-ECM (ventricular cardiac muscle-derived ECM). (B) F4/80+CD11b+ macrophage infiltrate. (C) CD11c+F4/80− dendritic cell infiltrate. (D) CD11b+Ly6c+ (immature monocytes) or Ly6g+ (polymorphonuclear cells; neutrophils, eosinophils, basophils). (E, F) Myeloid infiltrate in wild type (WT) (E) or Rag1−/− (F) mice, which lack mature T and B cells. Data shown for tissue-derived matrices (bone and cardiac ECM), collagen control, and saline vehicle control. Data are mean ± SEM, n = 4. Significance calculated by ANOVA.