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. 2017 Oct 1;23(19-20):1044–1053. doi: 10.1089/ten.tea.2016.0304

FIG. 7.

FIG. 7.

Myeloid profile is dependent on scaffold and presence of adaptive immune cells. (A) Characteristic CD86 increase and CD206 decrease in the absence of adaptive immune cells (Rag1−/−; red). (B) Decrease in CD11b+F4/80− cells in Rag1−/− mice. (C) CD11c expression on F4/80+CD11b+ macrophages is dependent on adaptive immune cells. Yellow box outlines population of interest. (D) Multiparametric analysis of surface markers on different myeloid subtypes. Data shown for tissue-derived bone ECM (+ECM) and saline vehicle control. Light blue line = CD11b+F4/80−Ly6c+ monocytes; Green line = CD11b+F4/80−Ly6g+ polymorphonuclear cells (PMNs, neutrophils, basophils eosinophils); Orange line = CD11b+/−F4/80−CD11c+ dendritic Cells; Red line = CD11b+F4/80+CD11clo macrophages; Blue line = CD11b+F4/80+CD11chi macrophages.