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. 2018 Nov 28;64(2):129–142. doi: 10.3164/jcbn.18-7

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Copyright © 2018 JCBN

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — The changes in α-tocopherol (αT) and α-tocopherylquinone (αTQ) concentrations in erythrocytes and plasma. The concentrations of αT (A) and αTQ (B) in erythrocytes were measured using HPLC-ECD. The ratio of αTQ to αT (αTQ/αT) in erythrocytes was calculated (C). (D) The correlation between αT and αTQ concentrations in erythrocytes. (E) The correlation between αT level and the ratio of αTQ/αT in erythrocytes. The concentrations of αT (F) and αTQ (G) and αTQ/αT ratio (H) in plasma were analyzed. (I) The correlation between the αT concentration in plasma and that in erythrocytes. (J) The correlation between plasma αT- and αTQ-concentration. (K) The correlation between αT level and the ratio of αTQ/αT in plasma. The data are expressed as mean ± SD. Statistical analysis was carried out using ANOVA. ^ap<0.05 compared to the initial (day 0) value of the same individual. To analyze the correlations, the normality of data distribution was assessed using the Shapiro-Wilk test, and the correlations were assessed by Spearman’s exact test. Solid diamonds indicate probucol 200 mg/kg/day macaque group. Open circles indicate probucol 400 mg/kg/day administered macaque group.