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. 2018 Nov 28;64(2):129–142. doi: 10.3164/jcbn.18-7

Fig. 6.

Fig. 6

Changes in the levels of linoleic acid- and cholesterol-derived peroxidation products in plasma. The plasma concentrations of EE-HODE [the sum of 9-(E,E)-HODE and 13-(E,E)-HODE] (A), ZE-HODE [the sum of 13-(Z,E)- and 9-(E,Z)-HODE] (B) and total HODE (tHODE; the sum of 4-isomers of HODEs) (C) were measured using LC-MS/MS. The ratio of ZE-HODE to EE-HODE (ZE/EE) in plasma was calculated (D). The plasma concentrations of LA (E) was measured using GC-MS, and the ratio of tHODE in LA (tHODE/LA) was calculated (F). The plasma concentrations of 7β-OHCh (G) and tCh (H) were measured using GC-MS, and the ratio of 7β-OHCh in tCh (7β-OHCh /tCh) was calculated (I). Solid diamonds indicate the probucol 200 mg/kg/day administered macaque group. Open circles indicate the probucol 400 mg/kg/day administered macaque group. The data are expressed as mean ± SD. Statistical analysis was carried out using ANOVA. ap<0.05 compared to the initial (day 0) value of same individual.