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. 2019 Mar 14;10:177. doi: 10.3389/fphys.2019.00177

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Copyright © 2019 Alves, de Queiroz, Bär and dos Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multidomain model for cardiac perfusion of the left ventricle. Each domain is modeled by a porous media. On the left side of the figure we have the domains that represent the intravascular flow in the heart: arterial domain (top), capillary domain (middle), and venous domain (bottom). On the right side of the figure we have the extravascular domain in the heart which is subdivided in interstitial space and fibrotic network (shaded area associate to an infarction). A recirculation circuit, which is a simplification of the pulmonary and systemic circulation processes, enforces a closed circuit.