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. 2019 Mar 14;10:177. doi: 10.3389/fphys.2019.00177

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Copyright © 2019 Alves, de Queiroz, Bär and dos Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Qualitative images in the end of first pass (50 s) and late enhancement (600 s) exams. In the first scenario (healthy), the CA is homogeneously distributed, while in the second (ischemia), the diseased region is revealed by low localized contrast values. At the time of late-enhancement, the CA gets stuck in the infarction region as reflected by the high localized contrast values. All the simulations reproduced well the characteristics seen by the clinicians in the considered scenarios.