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. 2019 Mar 14;10:177. doi: 10.3389/fphys.2019.00177

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Copyright © 2019 Alves, de Queiroz, Bär and dos Santos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) SI of the contrast agent in scenarios remote/healthy (red) and infarction (black). The yellow curve presents the clinical data taken from Knowles et al. (2008). The CA remains in the infarct area because it attaches to fibrosis, and thus takes longer to be washed out. (B) Contribution of both intra and extravascular spaces in the CA dynamics in the infarct region. The intravascular curve (purple) shows that the CA in this domain is quickly washed out, while the CA remains in the extravascular space (red curve) after 2 min.