Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Mar 13;10:244. doi: 10.3389/fphar.2019.00244

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Hansel, Erschfeld, Baues, Lammers, Weiskirchen, Trautwein, Kroy and Drescher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Expression of inhibitory T cell receptors PD1 and 2B4 increases on hepatic T cells under WD. (A) Blood and intrahepatic PD1 expressing CD8+ cells were analyzed by Flow Cytometry after SC and WD feeding for 24 weeks. (n = 5, ^∗p < 0.05 and ^∗∗∗p < 0.001). (B) Percentage of intrahepatic degranulating CD107a+ CD8 T cells of PD1+ and PD1- cells after SC or WD treatment for 24 weeks. (n = 5, ^∗p < 0.05). (C) Upregulation of PD1 on intrahepatic CD8+ CD62L+ (Naïve + central memory CD8+ T cells) and CD8+ CD62L- (effector memory CD8+ T cells) T cells after SC or WD. (n = 5, ^∗p < 0.05). (D) 2B4 expression on CD8+ T cells in blood and liver after SC or WD feeding for 24 weeks. (n = 5, ^∗p < 0.05). (E) PD1 expression on blood and hepatic CD4+ T cells under SC or WD for 24 weeks. (n = 5). (F) Inhibitory receptor 2B4 expression blood and intrahepatic CD4 T cells under SC or WD. (n = 5, ^∗p < 0.05).