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. 2019 Mar 15;10:157. doi: 10.3389/fendo.2019.00157

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Copyright © 2019 Kishikawa, Kitaura, Kimura, Ogawa, Qi, Shen, Ohori, Noguchi, Marahleh, Nara, Ichimura and Mizoguchi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DHA inhibits expression of LPS-induced TNF-α and RANKL via GPR120 in vivo. (A) Expression levels of RANKL mRNA in mouse calvariae in vivo. (B) Expression levels of TNF-α mRNA in mouse calvariae in vivo. TNF-α and RANKL mRNA levels were determined using real-time RT-PCR. Total RNA from mouse calvariae was isolated after 5 days of daily supracalvarial injections of PBS, LPS (100 μg/day), LPS (100 μg/day)+DHA (100 μg/day) with or without AH7614 (100 μg/day) and DHA (100 μg/day). Expression levels of RANKL and TNF-α mRNA were normalized to that of GAPDH. Data are shown as means ± SD (n = 4; ^**p < 0.01, ^*p < 0.05). Differences were determined by one-way ANOVA and Tukey-Kramer tests.