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. 2019 Mar 18;9:141. doi: 10.3389/fonc.2019.00141

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Copyright © 2019 Alborghetti, Correa, Whangbo, Shi, Aricetti, Silva, Miranda, Sforca, Caldana, Gerszten, Ritz and Zeri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis to leucine at day +100. BCAA blood concentrations were well correlated to leucine concentration at (A) discovery cohort and (B) validation cohort. Other correlated metabolites in both cohorts were tyrosine, histidine, arginine, ornithine, methionine, and asparagine, showing evidence of overall consistence of metabolic profile measurements in both cohorts. 2-oxo-isocaproate and 3-methyl-2oxovalerate, BCAA degradation products, were also well-correlated in the discovery cohort. These BCAA degradation products were not detected by LC-MS/MS platform on validation cohort.